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The preferred method for administering epinephrine during cardiac arrest is through a peripheral intravenous (IV) line. This approach is favored for a few key reasons.

A peripheral IV allows for rapid delivery of medications directly into the bloodstream, which is crucial during cardiac arrest when time is of the essence and immediate effects are required. The peripheral route is generally easier and faster to establish than other methods in urgent situations, making it very practical for emergency responders who need to provide treatment without delay.

While intraosseous access is an alternative that can be used, particularly when IV access is challenging, it is typically not the first-line choice unless peripheral access cannot be established in a timely manner. Central venous catheters, although effective, require a more invasive procedure, which can delay the administration of medications during critical moments like cardiac arrest. Oral administration is not suitable in this situation because it takes too long for the medication to be absorbed and effectively enter the circulation, which is not appropriate given the urgency of cardiac arrest scenarios.